Neural Basis of Motor Control
The Levine Lab
Levine Lab Publications
2026
Nicola, F; Li, L; Riesenmy, T; Parsley, R; Roome, RB; Markowitz, JE; Levine, AJ. (2026) A spinal substrate for modular control of natural behavior. BioRxiv.
Roome, RB; Yadav A; Flores, L; Puarr, A; Nardini, D; Richardson, A; Waclaw, RR; Arkell, RM; Menon, V; Johnson, JE; Levine, A. (2026) Ontogeny of the spinal cord dorsal horn. Science 391, eadx5781.
2025
Ignatyev, Y; Papadopoulos, S; Soretic, M; Yeung, J; Lin TY; Tanaka, EM; Peshkin, L; Levine, AJ; Gabitto, MI; Sweeney, LB. (2025) Innovations in spinal cord cell type heterogeneity across vertebrate evolution. BioRxiv.
2024
Bonev, B; ... Levine, A; ... Nowakowski, TJ. (2024) Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery. Nature Neuroscience, 27:2292.
2023
Yadav, A; Matson, KJE; Lee, D; Alkaslasi, MR; Roome, RB; Ward, ME; Phatnani, H; Le Pichon, CE; Menon, V; Levine, AJ. (2023) A reproducible signature of cytoskeletal and ALS-related genes in human motoneurons. Neuron, 6: 3742.
R. Brian Roome and Ariel J. Levine (2023). The Organization of Spinal Neurons: Insights from Single Cell RNA Sequencing. Current Opinion in Neurobiology, 82:102762.
Archana Yadav*, Kaya J.E. Matson*, Li Li, Isabelle Hua, Joana Petrescu, Kristy Kang, Mor R. Alkaslasi, Dylan I. Lee, Saadia Hasan, Ahmad Galuta, Annemarie Dedek, Sara Ameri, Jessica Parnell, Mohammad M. Alshardan, Feras Abbas Qumqumji, Saud M. Alhamad, Alick Pingbei Wang, Gaetan Poulen, Nicolas Lonjon, Florence Vachiery-Lahaye, Pallavi Gaur, Mike A. Nalls, Yue A. Qi, Michael E. Ward, Michael E. Hildebrand, Pierre-Francois Mery, Emmanuel Bourinet, Luc Bauchet, Eve C. Tsai, Hemali Phatnani, Claire E. Le Pichon, Vilas Menon#, Ariel J. Levine# (2023). A Cellular Taxonomy of the Adult Human Spinal Cord. Neuron. 111:328 *equal contribution; #co-corresponding.
Gao, C., Gohel, C.A., Leng, Y., Goldman, D., Levine, A.J., Penzo, M.A. (2022) Molecular and spatial profiling of the paraventricular nucleus of the thalamus. eLife 12:e81818
Koch, SC; Levine, AJ. (2023) The Neuronal Cell Types of the Spinal Cord. Spinal Interneurons, Elsevier.
2022
Kathe, C. et al…Matson, K.J.E.;… Levine, A.J., Wagner, F.; Bloch, J.; Squair J.W.; Courtine, G. (2022) The Neurons That Restore Walking After Paralysis. Nature 611:540 doi: 10.1038/s41586-022-05385-7
Matson, K.J.E., Russ, D.E., Kathe, C., Maric, D., Hua, I., Maric, D., Ding, Y., Krynitsky, J., Pursley, R., Sathyamurthy, A., Squair, J.W., Levi, B.P., Courtine, G., and Levine, A.J. (2022). A Single Cell Atlas of Spared Tissue Below a Spinal Cord Injury Reveals Cellular Mechanisms of Plasticity. Nature Communications 13:5628
2021
Do Couto Nicola, F; Hua, I; Levine, AJ. (2021) Intersectional Genetic Tools to Study Skilled Reaching in Mice. Experimental Neurology.
Squair, JW; Gautier, M; Kathe, C; Anderson, MA; James, ND; Hutson, T; Hudelle, R; Qaiser, T; Matson, KJE; Barraud, Q; Levine, AJ; La Manno, G; Skinnider, MA; Courtine, G. (2021) Confronting false discoveries in single-cell differential expression. Nature Communications, 12:5692.
Russ, ED*; Patterson-Cross, RB*; Li, L; Koch, SC; Matson, KJE; Levine, AJ. (2021) A Harmonized Atlas of Spinal Cord Cell Types and Their Spatial Organization. Nature Communications, 12:5722.
Barik, A; Sathyamurthy, A; Thompson, JH; Seltzer, M; Levine, AJ; Chesler AT. (2021) A spinoparabrachial circuit defined by Tacr1 expression drives pain. eLife 10:e61135.
Patterson-Cross, RB; Levine, AJ*; Menon, V*. (2021) Selecting single cell clustering parameter values using subsampling-based robustness metrics. BMC Bioinformatics 22, 39. *co-corresponding.
2020
Skinnider, MA; Squair, JW; Kathe, C; Anderson, MA; Gautier, M; Matson, KJE; Milano, M; Hutson, TH; Barraud, Q; Phillips, AA; Foster, LJ; La Manno, G; Levine, AJ; Courtine, G. (2020) Cell Type Prioritization in Single-Cell Data. Nature Biotechnology 39:30.
Sathyamurthy, A; Barik, A; Dobrott, CI; Chesler, AT; Levine, AJ. (2020) Cerebellospinal neurons regulate motor performance and motor learning. Cell Reports, 31: 107595.
2019
Dobrott, CI; Sathyamurthy, A; Levine, AJ. (2019) Decoding Cell Type Diversity Within the Spinal Cord. Current Opinion in Physiology, 8:1-6.
2018
Matson, KJE; Sathyamurthy, A; Johnson, KR; Kelly, MC; Kelley, MW; Levine, AJ. (2018) Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-Nucleus RNA Sequencing. Journal of Visualized Experiments, 140:e58413.
Sathyamurthy, A*; Johnson, KR*; Matson, KEJ; Li, Li; Ryba, AR; Bergman, TB; Dobrott, CI; Kelly, MC; Kelley, MW; Levine, AJ. (2018) Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity During Behavior. Cell Reports, 22: 2216-2225. *equal contribution.
Hayashi, M; Hinckley, CA; Driscoll, SP; Moore, NJ; Levine, AJ; Hilde, KL; Sharma, K; Pfaff, SL. (2018) Graded arrays of spinal and supraspinal V2a interneuron subtypes underlie forelimb and hindlimb motor control. Neuron, 97:869-884.
2012-2016
Hilde, KL; Levine, AJ; Hinckley, CA; Hayashi, M; Montgomery, JM; Gullo, M; Driscoll, SP; Grosschedl, R; Kohwi, Y; Kohwi-Shigematsu, T; Pfaff, SL. (2016) Satb2 is required for the development of a spinal exteroceptive microcircuit that modulates limb position. Neuron, 91:763-776.
Pawar, K; Cummings, B; Thomas, A; Shea, L; Levine, A; Pfaff, S; Anderson, A (2015) Biomaterial bridges enable regeneration and re-entry of corticospinal tract axons into the caudal spinal cord after SCI: association with recovery of forelimb function. Biomaterials, 65:1-12.
Levine, AJ*, Hinckley, CA*, Hilde, KL, Driscoll, SP, Poon, TH, Montgomery, JM, Pfaff, SL (2014) Identification of a cellular node for motor control pathways. Nature Neuroscience, 17:586:593. *equal contribution
Levine, AJ; Lewallen, KA; Pfaff, SL. (2012) Spatial organization of cortical and spinal neurons controlling motor behavior. Current Opinions in Neurobiology, 22:812-21.
2002-2012
Levine AJ and Brivanlou AH. (2010) The Molecular Basis of Pluripotency. Principles of Regnerative Medicine. Edited by A. Atala, R. Lanza, J. Thomson, R. Nerem. ISBN. 978-0-12-37085-3. Academic Press.
Levine AJ, Levine ZJ, Brivanlou AH. (2009) GDF3 is a BMP Inhibitor that can activate Nodal signaling only at very high doses. Developmental Biology 325: 43-48.
Levine AJ and Brivanlou AH. (2007) Proposal of a model of mammalian neural induction. Developmental Biology308:247-256.
Levine AJ and Brivanlou AH (2006) GDF3 at the crossroads of TGF-beta signaling. Cell Cycle 10: 1069-1073.
Levine AJ and Brivanlou AH. (2006) GDF3, a BMP inhibitor regulates cell fate in stem cells and early embryos. Development 133:209-216.
James D, Levine AJ, Besser D, Hemmati-Brivanlou A. (2005) TGFB/activtin/nodal signaling is necessary for the maintenance of pluripotency in the human embryonic stem cells. Development 132:1273-1282.
Levine AJ, Munos-Sanjuan I, Bell E, North AJ, Brivanlou AH. (2003) Fluorescent labeling of endothelial cells allows in vivo, continuous characterization of the vascular development of Xenopus laevis. Developmental Biology 254:50-67.
Mishra L, Cai T, Levine A, Weng D, Mezey E, Misra B, Gearhart J. (2002) Identification of elf1, a beta-spectrin, in early mouse liver development. Int’l J of Developmental Biology 42:221-4.